Pediatric Otolaryngologist - Scientist
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Relationship between inflammation and the severity of Recurrent Respiratory Papillomatosis.

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Relationship between inflammation and the severity of Recurrent Respiratory Papillomatosis.

Am J Otolaryngol. 2019 Nov 18;:102321

Authors: El Achkar VNR, Duarte A, Carlos R, León JE, Ribeiro-Silva A, Pignatari SSN, Kaminagakura E

Abstract
OBJECTIVE: To characterize inflammatory cells in Recurrent Respiratory Papillomatosis (RRP) and to correlate it with severity using the Derkay laryngoscopic scale.
MATERIALS AND METHODS: The data and biopsies from 36 patients with Juvenile (JRRP) and 56 patients with Adult (ARRP) were collected and analyzed under light microscopy. The patients were separated into groups according to the Derkay index: ≥20 for the most severe and < 20 for the less severe cases. Immunohistochemical analysis using CD3, CD4, CD8, CD15, CD20, CD68, FoxP3 and MUM-1 antibodies was performed, and the inflammatory cells were quantified. All the clinicopathological characteristics and the results of the immunohistochemical analysis were compared among the groups proposed using the Chi-Square test and correlated through the Spearman correlation test.
RESULTS: The ARRP showed significantly higher quantities of CD3+, CD8+ and MUM1+ cells (p < .05) than the JRRP samples. The presence of CD15+ cells showed positive correlation with the Derkay index (p < .05), while the MUM-1+ cells showed an inverse correlation (p = .01).
CONCLUSION: There are differences between the inflammatory cells population in the juvenile and adult groups and it can be related to disease severity.

PMID: 31787356 [PubMed - as supplied by publisher]

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FarrelBuch
65 days ago
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Would be interesting to compare to subsequent remission vs not
Pittsburgh, PA, USA

The Modjadji Cycad

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Encephalartos transvenosus is a palm-like cycad found in the mountains of Limpopo Province, South Africa, particularly on two hills near Duivelskloof. Its common name, Modjadji cycad, alludes to the female dynasty of the Lobedu people, the Rain Queens, whose hereditary name is Modjadji. The queen resides near a valley (of late a nature reserve) which is densely forested with these cycads, which they protected and hold sacred. It is a tall majestic tree and has been protected by generations of rain-queens. It forms pure forests on these hills, the only cycad forests in Southern Africa.

As a garden subject, Encephalartos transvenosus, with its glossy dark-green leaves, is one of the most spectacular and tallest of all cycad species. It is also one of the fastest growing, developing to a height of 6 to 8m or more with a leaf spread of up to 5m. The plants produce cones with the male and female cones being produced on separate plants. Male cones develop to a length of 300-400mm; the female cones are very large and heavy. The cones are golden brown in colour and are produced in late summer, weighing more than 40 kg.


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International Pediatric Otolaryngology Group (IPOG): Juvenile-onset recurrent respiratory papillomatosis consensus recommendations.

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International Pediatric Otolaryngology Group (IPOG): Juvenile-onset recurrent respiratory papillomatosis consensus recommendations.

Int J Pediatr Otorhinolaryngol. 2019 Sep 28;128:109697

Authors: Lawlor C, Balakrishnan K, Bottero S, Boudewyns A, Campisi P, Carter J, Cheng A, Cocciaglia A, DeAlarcon A, Derkay C, Fayoux P, Hart C, Hartnick C, LeBoulanger N, Moreddu E, Muntz H, Nicollas R, Peer S, Pransky S, Rahbar R, Russell J, Rutter M, Seedat R, Sidell D, Smith R, Soma M, Strychowsky J, Thompson D, Triglia JM, Trozzi M, Wyatt M, Zalzal G, Zur KB, Nuss R

Abstract
OBJECTIVES: To develop consensus recommendations for the evaluation and management of juvenile-onset recurrent respiratory papillomatosis (JORRP) in pediatric patients.
METHODS: Expert opinion by the members of the International Pediatric Otolaryngology Group (IPOG). The mission of the IPOG is to develop expertise-based consensus recommendations for the management of pediatric otolaryngologic disorders with the goal of improving patient care. The consensus recommendations herein represent the first publication by the group.
RESULTS: Consensus recommendations including diagnostic considerations, surgical management, systemic adjuvant therapies, postoperative management, surveillance, and voice evaluation. These recommendations are based on the collective opinion of the IPOG members and are targeted for otolaryngologists, primary care providers, pulmonologists, infectious disease specialists, and any other health care providers that manage patients with JORRP.
CONCLUSIONS: Pediatric JORRP consensus recommendations are aimed at improving care and outcomes in this patient population.

PMID: 31698245 [PubMed - as supplied by publisher]

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FarrelBuch
101 days ago
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Very good guide for norms of practice
Pittsburgh, PA, USA

How Hacking Works

6 Comments and 20 Shares
If only somebody had warned them that the world would roll them like this.
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fxer
221 days ago
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As sysadmin of the smash mouth message boards I stand by my decision to store the plaintext passwords next to the md5, in case I want to upgrade the hash later.
Bend, Oregon
tedder
195 days ago
Password hint: $entire_password
reconbot
222 days ago
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My personal threat model
New York City
163 days ago
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BalooUriza
222 days ago
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Is Venmo a thing?
Tulsa, Oklahoma
Brstrk
223 days ago
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SomeBODY has failed to setup proper Netsec.
Ferret
223 days ago
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This is entirely true.
alt_text_bot
223 days ago
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If only somebody had warned them that the world would roll them like this.
pedersje
223 days ago
Well, they weren't the sharpest tools in the shed.

Chernobyl

3 Comments and 11 Shares
You know when you can't hear your speakers, and you keep turning various volume controls up higher and higher in confusion, and then someone hits the mute button and there's a deafening blast of sound? That's basically what happened at Chernobyl.
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FarrelBuch
250 days ago
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Best documentary/dramatized documentary I have ever seen. The accompanying podcast series is also brilliant
Pittsburgh, PA, USA
nloveladyallen
254 days ago
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He should write a book of stuff like this
Takoma Park, Maryland
sirwired
254 days ago
He did: "Thing Explainer: Complicated Stuff in Simple Words"
nloveladyallen
254 days ago
@sirwired That’s the joke
trekkie
254 days ago
it actually hurt my head to try and read that book
ManBehindThePlan
253 days ago
I see what you did there :)
alt_text_bot
254 days ago
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You know when you can't hear your speakers, and you keep turning various volume controls up higher and higher in confusion, and then someone hits the mute button and there's a deafening blast of sound? That's basically what happened at Chernobyl.

Amazon’s Antitrust Antagonist Has a Breakthrough Idea

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Lina Khan’s writing has rocked the antitrust establishment — and made her an unlikely celebrity in Washington policy circles.

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